Fenbendazole, sold under the brand name Pancur or Safe-Guard, is a broad spectrum benzimidazole anthelmintic approved for use in many animals, including horses, dogs, cats, and rabbits, as a treatment for parasites and worms. It is also used in freshwater shrimp tanks as a parasite treatment for hydra and planaria.

In early July 2019, a patient with metastatic breast cancer came to our clinic for evaluation, as her CEA levels had recently increased and she wanted to explore new therapies. She had been undergoing treatment with pembrolizumab and was concerned about progression. In her search for information on new treatment methods, she had stumbled upon the Joe Tippens Protocol, a regimen that includes fenbendazole.

Joe Tippens Protocol is a controversial method of treating cancer with supplements and medications, most of which are not FDA-approved or clinically tested. While this protocol has gained a large following online, the science behind it is unclear and the risks are significant.

Several studies have shown that fenbendazole has antitumor effects in animal models. In one study, athymic nude mice with human nonsmall cell lung adenocarcinoma tumors were treated for 12 days with 1 mg fenbendazole daily, which significantly decreased tumor size and vascularity. This effect was accompanied by the decrease in expression of RAS-related signaling pathways.

In a more recent study, graded doses of fenbendazole were administered to EMT6 cells in culture, followed by x-ray radiation. The results showed that fenbendazole has both a microtubule depolymerizing and an autophagic effect on the cells, and both effects are synergistic when combined with Vitamin C. fenbendazole capsules

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